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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
38.18
Human Site:
Y199
Identified Species:
56
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
Y199
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Chimpanzee
Pan troglodytes
XP_525364
403
45791
Y199
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
Y271
N
I
L
R
L
Y
N
Y
F
H
D
A
R
R
V
Dog
Lupus familis
XP_853397
405
45606
Y200
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
Y190
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Rat
Rattus norvegicus
P59241
397
44856
Y192
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
Y106
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
Chicken
Gallus gallus
XP_425725
409
46456
H201
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
Frog
Xenopus laevis
Q91819
408
46443
Y206
N
I
L
R
L
Y
G
Y
F
H
D
A
S
R
V
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
D123
F
Y
N
Y
F
H
D
D
T
R
V
F
L
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
E131
S
R
I
Y
L
A
L
E
I
A
S
E
G
E
L
Honey Bee
Apis mellifera
XP_395732
327
37711
Y130
N
I
L
K
M
Y
G
Y
F
H
D
D
K
R
I
Nematode Worm
Caenorhab. elegans
O01427
305
34731
E108
K
K
I
Y
L
V
L
E
Y
A
P
G
G
E
M
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
V81
Y
F
Y
D
E
S
R
V
Y
L
I
L
E
Y
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
Y85
N
I
L
R
L
Y
G
Y
F
Y
D
Q
K
R
V
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
Y170
N
L
T
K
S
Y
G
Y
F
H
D
E
K
R
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
86.6
100
N.A.
100
100
N.A.
6.6
0
93.3
0
N.A.
6.6
66.6
6.6
0
P-Site Similarity:
100
100
86.6
100
N.A.
100
100
N.A.
6.6
26.6
100
13.3
N.A.
26.6
86.6
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
80
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
7
0
0
0
13
0
44
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
0
0
7
7
0
0
63
7
0
0
0
% D
% Glu:
0
7
0
7
7
0
0
13
0
0
0
19
7
13
0
% E
% Phe:
13
7
0
0
7
0
0
0
63
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
57
0
0
0
0
7
13
0
0
% G
% His:
0
7
0
0
0
7
0
7
0
57
7
0
0
0
0
% H
% Ile:
0
57
13
0
7
0
0
0
7
7
7
0
0
13
7
% I
% Lys:
7
7
0
13
0
0
0
0
0
0
0
0
19
0
0
% K
% Leu:
0
7
57
0
63
0
13
0
13
7
7
7
7
0
19
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
63
0
7
0
0
0
7
0
0
0
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
7
7
0
0
7
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
0
7
0
0
0
% Q
% Arg:
7
7
0
50
0
7
7
0
0
13
0
0
7
63
0
% R
% Ser:
7
0
0
0
7
7
7
0
0
0
7
0
7
0
0
% S
% Thr:
0
0
7
0
7
0
0
0
7
0
0
0
32
0
0
% T
% Val:
0
0
7
0
0
7
7
7
0
0
7
0
0
0
57
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
7
19
0
63
0
69
13
7
0
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _